Michela Mattioli's foto

Michela Mattioli

Research Technologist

IIT@SEMM

Phone +39 02 9437 5112

Bio

Research experience:

2009-2011:   Head Cellular Assays Unit, Therasis Inc., New York, USA

2007-2009:   Senior Scientist, Dept. of Sciences and Biomedical Technologies, University of Milan, Italy

2005-2007:   Research Scientist, Target Biology Group, Axxam SpA, Milan, Italy

2003-2005:   Research Scientist, Centro di Genetica Molecolare ed Espressione Genica, Fondazione IRCCS Policlinico, Milan, Italy

1999-2002:   Postdoctoral Fellow, Institute for Cancer Genetics, Columbia University, New York, USA (Advisor:  R. Dalla-Favera)

1995-1999:   Research Fellow, Dept. of internal Medicine, Ospedale Maggiore Policlinico, Milan, Italy (Advisor: S. Fargion)

Education:

2004: Post Grad, Science Communication, University of Milan

2002: PhD, Gastroenterology, University of Milan

1995: Degree, Biological Sciences, University of Milan

Other Publications

Selected publications:

  • Cassinelli G, Ronchetti D, Laccabue D, Mattioli M, Cuccuru G, Favini E, Nicolini V, Greco A, Neri A, Zunino F, Lanzi C. Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting. Biochem Pharmacol. 2009; 78(9):1139-47.
  • Ria R, Todoerti K, Berardi S, Coluccia AM, De Luisi A, Mattioli M, Ronchetti D, Morabito F, Guarini A, Petrucci MT, Dammacco F, Ribatti D, Neri A, Vacca A. Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma. Clin Cancer Res. 2009; 15(17):5369-78.
  • Lombardi L, Poretti G, Mattioli M, Fabris S, Agnelli L, Bicciato S, Kwee I, Rinaldi A, Ronchetti D, Verdelli D, Lambertenghi-Deliliers G, Bertoni F, Neri A. Molecular characterization of human multiple myeloma cell lines by integrative genomics: insights into the biology of the disease. Genes Chromosomes Cancer. 2007; 46(3):226-38.
  • Piva R*, Pellegrino E*, Mattioli M, Agnelli L, Lombardi L, Boccalatte F, Costa G, Ruggeri BA, Cheng M, Chiarle R, Palestro G, Neri A, Inghirami G. Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes. J Clin Invest. 2006;116(12):3171-82.
  • Severgnini M, Bicciato S, Mangano E, Scarlatti F, Mezzelani A, Mattioli M, Ghidoni R, Peano C, Bonnal R, Viti F, Milanesi L, De Bellis G, Battaglia C. Strategies for comparing gene expression profiles from different microarray platforms: application to a case-control experiment. Anal Biochem. 2006;353(1):43-56.
  • Pruneri G, Ponzoni M, Ferreri AJ, Freschi M, Tresoldi M, Baldini L, Mattioli M, Agnelli L, Govi S, Mancuso P, Agazzi A, Bertolini F, Peccatori J, Bosari S, Gianelli U, Viale G, Neri A. The prevalence and clinical implications of c-kit expression in plasma cell myeloma. Histopathology. 2006;48(5):529-35.
  • Verdelli D, Mattioli M, Fabris S, Nobili L, Intini D, Guerneri S, Todoerti K, Zanella A, Deliliers GL, Lombardi L, Neri A. Molecular and biological characterization of three novel interleukin-6-dependent human myeloma cell lines. Haematologica. 2005;90(11):1541-8.
  • Agnelli L*, Bicciato S*, Mattioli M, Fabris S, Intini D, Verdelli D, Baldini L, Morabito F, Callea V, Lombardi L, Neri A. Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients ex pressing CCND1 and negative for 14q32 translocations. J Clin Oncol. 2005;23(29):7296-306.
  • Vacca A*, Scavelli C*, Montefusco V, Di Pietro G, Neri A, Mattioli M, Bicciato S, Nico B, Ribatti D, Dammacco F, Corradini P. Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol. 2005;23(23):5334-46.
  • Mattioli M*, Agnelli L*, Fabris S, Baldini L, Morabito F, Bicciato S, Verdelli D, Intini D, Nobili L, Cro L, Pruneri G, Callea V, Stelitano C, Maiolo AT, Lombardi L, Neri A. Gene expression profiling of plasma cell dyscrasias reveals molecular patterns associated with distinct IGH translocations in multiple myeloma. Oncogene. 2005;24(15):2461-73.
  • Fabris S, Agnelli L, Mattioli M, Baldini L, Ronchetti D, Morabito F, Verdelli D, Nobili L, Intini D, Callea V, Stelitano C, Lombardi L, Neri A. Characterization of oncogene dysregulation in multiple myeloma by combined FISH and DNA microarray analyses. Genes Chromosomes Cancer. 2005;42(2):117-27.
  • Qi CF, Martensson A, Mattioli M, Dalla-Favera R, Lobanenkov VV, Morse HC 3rd. CTCF functions as a critical regulator of cell-cycle arrest and death after ligation of the B cell receptor on immature B cells. PNAS. 2003;100(2):633-8.
  • Wu KJ*, Mattioli M*, Morse HC 3rd, Dalla-Favera R. c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cbeta) gene. Oncogene. 2002;21(51):7872-82.
  • Klein U, Tu Y, Stolovitzky GA, Mattioli M, Cattoretti G, Husson H, Freedman A, Inghirami G, Cro L, Baldini L, Neri A, Califano A, Dalla-Favera R. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells. J Exp Med. 2001;194(11):1625-38.
  • Ma Y, Fracanzani AL, Sampietro M, Mattioli M, Cheeseman P, Williams R, Mieli-Vergani G, Vergani D, Fargion S. Autoantibodies to human cytosol: a marker of sporadic porphyria cutanea tarda. Clin Exp Immunol. 2001;126(1):47-53.
  • Fargion S, Mattioli M, Fracanzani AL, Sampietro M, Tavazzi D, Fociani P, Taioli E, Valenti L, Fiorelli G. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol. 2001;96(8):2448-55.
  • Fargion S, Valenti L, Dongiovanni P, Scaccabarozzi A, Fracanzani AL, Taioli E, Mattioli M, Sampietro M, Fiorelli G. Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis. Blood. 2001;97(12):3707-12.
  • Fracanzani AL, Conte D, Fraquelli M, Taioli E, Mattioli M, Losco A, Fargion S. Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease. Hepatology. 2001;33(3):647-51.
  • Scaccabarozzi A, Arosio P, Weiss G, Valenti L, Dongiovanni P, Fracanzani AL, Mattioli M, Levi S, Fiorelli G, Fargion S. Relationship between TNF-alpha and iron metabolism in differentiating human monocytic THP-1 cells. Br J Haematol. 2000;110(4):978-84.
  • Zuccon L, Corsi B, Levi S, Mattioli M, Fracanzani AL, Corti A, Albertini A, Sampietro M, Fargion S, Arosio P. Immunohistochemistry of HFE in the duodenum of  C282Y homozygotes with antisera for recombinant HFE protein. Haematologica. 2000;85(4):346-51.

*contributed equally