These projects aim at de convoluting cancer-associated pathways exploting chemical diversity. Compound libraries will be screened against cancer-relevant phenotypes or pathways and the identified small molecules used to identify protein targets through proteomic, biological and genetic approaches.

Pivotal to the success of these approaches is the set-up of a robotized, imaging-based, high-throughput and high-content platform for the execution of cell-based (genetic and chemical) screenings.