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Gabriella Panuccio

Researcher - Principal Investigator
Enhanced Regenerative Medicine
Research center

I am a Medical Doctor and I hold a Ph.D. in Biophysics. I use microelectrode array electrophysiology in brain slices, primary brain cell spheroids and stem cell-derived brain organoids to study neuronal electrical activity in health and disease at the network level. I have a strong background in epilepsy research and a multidisciplinary expertise including neurophysiology, theoretical neuroscience and neural engineering, built across several years of national and international research experience, started with my MD Thesis.

My scientific work focuses on the development of intelligent biohybrid systems for functional brain repair, that would be capable of self-reconfiguration to recover the function of diseased brain circuits by dynamically interacting with them, thus being tailored to the individual.

In the context of the H2020 MSCA-IF founded project Re.B.Us. I have pushed forward the joint exploitation of biological and artificial components based on unidirectional and bidirectional closed-loop architectures to demonstrate the feasibility of reconnecting disconnected limbic areas via biohybrid bridging approach, ultimately deploying this paradigm in a biohybrid graft-host interaction in an in vitro model of mesial temporal lobe epilepsy. www.rebus-project.eu

I currently coordinate the H2020-FET-PROACTIVE project HERMES joining a multidisciplinary EU consortium of 12 partners (~70 people to date) with expertise in neurobiology, neurophysiology and biophysics, stem cell biotechnology, biomaterials, tissue bioengineering, materials science, neuromorphic engineering, machine learning and AI, ethics, policy and philosophy. www.hermes-fet.eu. The long-term vision of HERMES is healing disabling brain disorders by means of brain tissue transplants, a reality that is only possible to date for other organs of the human body. To overcome the biological uncertainty of canonical regenerative approaches, HERMES proposes an innovative solution based on intelligent biohybrids in which the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence effectively pursues a self-repair process of dysfunctional brain circuits. In light of its vision, HERMES fosters the emergence of a novel paradigm to heal rather than treat the diseased brain. This paradigm is named enhanced regenerative medicine and is rooted in the establishment of biohybrid neuronics (neural electronics), bringing together the best of biological and artificial worlds to allow for controlled brain regeneration.

All Publications
Della Rosa G., Gostynska N. E., Wesley Ephraim J., Sganga S., Panuccio G., Palazzolo G., Tirelli N.
Magnesium alginate as a low-viscosity (intramolecularly cross-linked) system for the sustained and neuroprotective release of magnesium
Carbohydrate Polymers, vol. 331
Article Journal
Della Rosa G., Gostynska N., Ephraim J.W., Marras S., Moroni M., Tirelli N., Panuccio G., Palazzolo G.
Magnesium vs. sodium alginate as precursors of calcium alginate: Mechanical differences and advantages in the development of functional neuronal networks
Carbohydrate Polymers, vol. 342
Article Journal
Panuccio G., Puthanmadam Subramaniyam N., Canal-Alonso A., Corchado J.M., Ierna C.
Using AI to Steer Brain Regeneration: The Enhanced Regenerative Medicine Paradigm.
Big Data Analysis and Artificial Intelligence for Medical Sciences, Publisher: Wiley
Book Chapter Book
De Los Rios I.D., Wesley Ephraim J., Palazzolo G., Serrano-Gotarredona T., Panuccio G., Linares-Barranco B.
A Memristor-Inspired Computation for Epileptiform Signals in Spheroids
AICAS 2023 - IEEE International Conference on Artificial Intelligence Circuits and Systems, Proceeding
Conference Paper Conference
Caron D., Buccelli S., Canal-Alonso A., Farsani J., Pruzzo G., Barranco B.L., Corchado J.M., Chiappalone M., Panuccio G.
Biohybrid restoration of the hippocampal loop re-establishes the non-seizing state in an in vitro model of limbic seizures
Journal of Neural Engineering, vol. 20, (no. 4)
Article Journal
Panuccio G.
Simbiosi bioartificiali per rigenerare il cervello
Public Event
Panuccio G.
The HERMES Project: ENhancing the Future of Brain Regeneration
Panariello Scientifico
Public Event
Panuccio G., Chiappalone M., Colombi I.
Da grande voglio fare il neuroscienziato
Istituto Comprensivo Sanvitale Fra Salimbene
Scientific Talks
Panuccio G.
The HERMES Project – Enhancing the Future of Brain Regeneration
Osnabrück University
Panuccio G.
Enhanced Regenerative Medicine: Where Biology and Engineering Meet
UK Circuits and Systems (UKCAS) for Biomedical Applications
Oral presentations
Panuccio G., Avoli M.
Subiculum, GABAergic inhibition and temporal lobe epilepsy Subiculum, inibizione GABAergica ed epilessia del lobo temporale
Bollettino - Lega Italiana contro l'Epilessia, (no. 142), pp. 92-95