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Gian Gaetano Tartaglia

Principal Investigator
Senior Researcher Tenured - Principal Investigator
RNA Systems Biology
Phone
Address
Research center
About
I graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons supervised by Brunello Tirozzi (Physics department). Between 2001 and 2005, I carried out my doctoral studies at the University of Zurich CH with Amedeo Caflisch (Biochemistry department) focusing on the folding and misfolding of proteins associated with neurodegenerative disorders. As an associate researcher, I worked at the University of Cambridge UK (Chemistry and Genetics departments) under the supervision of Chris Dobson and Michele Vendruscolo. In the period 2005-2010, I participated in several computational and experimental studies on amyloidosis. I am life member of the Clare Hall College in Cambridge UK since 2011. From 2010 and until 2020 I have been PI at the Centre for Genomic Regulation (CRG) in Barcelona directed by Miguel Beato (until 2012) and Luis Serrano (since 2012), in the research program of Roderic Guigo'. I was awarded an ERC grant in 2013 for my studies on the role of coding and non-coding transcripts in regulation of amyloid genes. In 2014 I was tenured in Catalonia as ICREA professor of Life and Medical Sciences. In December 2018 I became full professor of Biochemistry in the Department of Biology at University La Sapienza. In 2019 I started to work at IIT. In 2020 I was awarded an ERC grant for the study on the composition of phase-separated assemblies. This ERC is a Synergy grant and involves collaboration with Giancarlo Ruocco and Irene Bozzoni. In march 2020 I became PI at IIT where I lead the RNA System Biology lab. Together with the official members of the group, there are also Dr. Claudia Giambartolomei and Dr. Elsa Zacco from the Non-coding RNAs and RNA-based therapeutics lab. Elsa and Claudia are the pioneers of our RNA System Biology lab and joined IIT in early 2019. Jakob Rupert, PhD student from Sapienza university, is also member of Tartaglia's lab. Edoardo Milanetti, Lorenzo Di Rienzo and Mattia Miotto, previously in Anna Tramontano's group and now working at IIT CNLS with Giancarlo Ruocco are honorary members of the lab. Since September 2020 I am MAE (Member of Academia Europaea).
Education

Title: Clare Hall Research Fellow - Genetics and Chemistry
Institute: University of Cambridge
Location: Cambridge
Country: UK
From: 2007 To: 2010

Title: PhD - Biochemistry
Institute: University of Zurch
Location: Zuerich
Country: Switzerland
From: 2001 To: 2006

Title: MSc - Physics
Institute: University of Rome Sapienza
Location: Rome
Country: Italy
From: 1996 To: 2000

Skills

Protein-RNA Networks

Phase Separation

RNA Viruses

Computational Modelling

RNA Chemistry

All Publications
2023
Asensio N.C., Rizzieri S., Cuomo A., Tartaglia G.G., Zacco E.
An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
Journal of Visualized Experiments, vol. 2023, (no. 192)
Article Journal
2023
Gerber A.P., Tartaglia G.G.
Editorial: Insights into RNA networks and biology
Frontiers in Molecular Biosciences, vol. 10
Editorial Journal
2023
Colantoni A., Capauto D., Alfano V., D'Ambra E., D'Uva S., Tartaglia G.G., Morlando M.
FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation
International Journal of Molecular Sciences, vol. 24, (no. 4)
2023
Mangoni D., Simi A., Lau P., Armaos A., Ansaloni F., Codino A., Damiani D., Floreani L., Di Carlo V., Vozzi D., Persichetti F., Santoro C., Pandolfini L., Tartaglia G. G., Sanges R., Gustincich S.
LINE-1 regulates cortical development by acting as lncRNAs
Nature Communications, vol. 14, pp. 4974
Article Journal
2023
Perez-Cabello J.A., Silvera-Carrasco L., Franco J.M., Capilla-Gonzalez V., Armaos A., Gomez-Lima M., Garcia-Garcia R., Yap X.W., Leal-Lasarte M., Lall D., Baloh R.H., Martinez S., Miyata Y., Tartaglia G.G., Sawarkar R., Garcia-Dominguez M., Pozo D., Roodveldt C.
MAPK/MAK/MRK overlapping kinase (MOK) controls microglial inflammatory/type-I IFN responses via Brd4 and is involved in ALS
Proceedings of the National Academy of Sciences of the United States of America, vol. 120, (no. 28)
Article Journal
Dissemination
2022
Tartaglia G.G.
This is Philosophy, about Aristotle
https://www.rtve.es/play/videos/this-is-philosophy/aristoteles/6297519/
Media
2021
Tartaglia G.G.
Big data and Artificial Intelligence in Biology
https://www.youtube.com/watch?v=3wL58kR_dYU
Media
2021
Tartaglia G.G.
L’unico compito di un virus è quello di riprodursi
https://opentalk.iit.it/lunico-compito-di-un-virus-e-quello-di-riprodursi/
Media
Scientific Talks
2023
Longaretti A., Mangoni D., Paget-Blanc V., Boender A.J., Pelloux Y., Lau P., Tartaglia G.G., Gustincich S., Tonini R.
Epigenetic plasticity at striatal circuits contributes to the transition from flexible to inflexible behavioural control
EMCCS - European Molecular and Cellular Cognition Society
Workshop/Symposium
2022
Tartaglia G.G.
Protein and RNA Networks in Cellular Condensation
PhasAGE Training School
Workshop/Symposium
2022
Tartaglia G. G.
RNA in molecular crowding
Molecular Crowding Workshop Grenoble
Conference
2022
Tartaglia G.G.
The role of RNA in Phase separation
Physics of Biomolecules: Structure, Dynamics and Function
Conference
2021
Vocino G., Vandelli A., Tartaglia G.G.
COMPARATIVE ANALYSIS OF SARS-COV-2 GENOME INTERACTIONS WITH HUMAN PROTEINS
Bachelor’s Degree in Genomics
School (Summer school, ...)
Awards and Achievements
2023
Ruocco G., Tartaglia G.G.
EIC Pathfinder Open ivBM
2023
Tartaglia G.G.
ERC Advanced Grant Referee
2022
Broglia L., Tartaglia GG.
EMBO Fellowship to L. Broglia
2022
Zacco E., Tartaglia GG., Horrocks M., Gregory J., Schneider N.
Probing RNA-binding protein aggregates at the nanoscale using in-silico-designed aptamers.
2020
Tartaglia G.G.
ERC Award
Editorships
2019-2039
Tartaglia G.G.
Nucleic Acids Research Genomics and Bioinformatics
2015-2035
Tartaglia G.G.
Frontiers in Molecular Biosciences
Organized Events
2022
De Pietri Tonelli D., Nicassio F., Tartaglia GG.
Co-coordinator of the “RNA Collaborative Seminar Series” by the RNA society (USA)