Francesca Milanesi

Lab manager

Research Lines

Genomic Science




via adamello 16



2010  PhD in Molecular Medicine at the European School of Molecular Medicine (SEMM)

IFOM-IEO Campus, Milan

2006  Second Level Degree in Biotechnology at University of Milano-Bicocca, Milan

2004  Bachelor's Degree in Biotechnology at University of Milano-Bicocca, Milan


Work Expirience:

may 2013-present          Lab manager at IIT@SEMM

march 2011-may 2013   Support technician at IIT@SEMM, screening Unit

jan 2011-march 2011     PostDoc at IFOM, in Giorgio Scita's laboratory

2006-2010                    PhD Student at IFOM, under the supervision of Prof. Giorgio Scita




Selected Publications

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP.

Disanza A, Bisi S, Winterhoff M, Milanesi F, Ushakov DS, Kast D, Marighetti P, Romet-Lemonne G, Müller HM, Nickel W, Linkner J, Waterschoot D, Ampè C, Cortellino S, Palamidessi A, Dominguez R, Carlier MF, Faix J, Scita G.


EMBO J. 2013 Oct 16;32(20):2735-50. doi: 10.1038/emboj.2013.208. Epub 2013 Sep 27.


Functional analysis and consequesnces of Mdm2 E3 ligases inhibition in human tumor cells.

Wade M, Li YC, Matani AS, Braun SM, Milanesi F, Rodewald LW, Wahl GM.

Oncogene. 2012 Jan 23. doi: 10.1038/onc.2011.625. [Epub ahead of print]

The Eps8/IRSp53/VASP network differentially controls actin capping and bundling in filopodia formation.

Vaggi F, Disanza A, Milanesi F, Di Fiore PP, Menna E, Matteoli M, Gov NS, Scita G, Ciliberto A.

PLoS Comput Biol. 2011 Jul;7(7):e1002088. Epub 2011 Jul 21.


Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.

Hertzog M, Milanesi F, Hazelwood L, Disanza A, Liu H, Perlade E, Malabarba MG, Pasqualato S, Maiolica A, Confalonieri S, Le Clainche C, Offenhauser N, Block J, Rottner K, Di Fiore PP, Carlier MF, Volkmann N, Hanein D, Scita G.

PLoS Biol. 2010 Jun 1;8(6):e1000387.


Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

Disanza A, Mantoani S, Hertzog M, Gerboth S, Frittoli E, Steffen A, Berhoerster K, Kreienkamp HJ, Milanesi F, Di Fiore PP, Ciliberto A, Stradal TE, Scita G.

Nat Cell Biol. 2006 Dec;8(12):1337-47. Epub 2006 Nov 19.