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Raffaella Tonini

Senior Researcher Tenured - Principal Investigator
Neuromodulation of Cortical and Subcortical Circuits
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About

To adapt to an ever-changing environment and to reach specific goals, the brain needs to learn to choose between different behavioral options. This neuronal processing is influenced by the activity of neuromodulatory systems that can report selective perceptual and motivational information over multiple timescales. Neuromodulators act through specialized receptors localized on anatomically different pathways to shape the activity of neurons as well as the strength and plasticity of their synapses.  However, we have a limited mechanistic understanding of how the temporal coding of neuromodulatory signals affects the interactions between brain regions for perception and reward to implement neuronal computations.

Our aim is to resolve the spatiotemporal dynamic of behaviorally relevant neuromodulatory signals at cellular resolution by using new tools for probing, analyzing, and engineering  micro- and macrocircuits of the brain.  

All Publications
2023
Boi L., Johansson Y., Tonini R., Moratalla R., Fisone G., Silberberg G.
Serotonergic and dopaminergic neurons in the dorsal raphe are differentially altered in a mouse model for Parkinson’s disease
bioarXiv
Article Journal
2022
Boi F., Angotzi G.N., Ribeiro J.F., Vincenzi M., Locarno A., Tonini R., Berdondini L.
A flexible and scalable CMOS-based neural probe technology for high-density full-band extracellualr brain mapping
Annual Meeting of the Society for Neuroscience 2022
Poster Conference
2022
Pelloux Y., Rais C., Veggi M., Nava L., Gino A., Tonini R.
Involvement of dorsal raphe nucleus serotoninergic projection to the dorsal striatum on behavioural switching in a probabilistic discrimination task
GRC Basal Ganglia
Poster Conference
2022
Pelloux Y., Rais C., Veggi M., Nava L., Gino A., Tonini R.
Involvement of serotoninergic projections to the dorsal striatum in behavioral switching under uncertainty
FENS Forum 2022, Paris, France
Poster Conference
2022
Longaretti A., Mangoni D., Paget-Blanc V., Boender A.J., Pelloux Y., Lau P., Tartaglia G. G., Gustincich S., Tonini R.
LINE-1 long non-coding RNAs at striatal circuits contributes to the transition from flexible to inflexible behavioral control
FENS Forum 2022, Paris, France
Abstract Report Conference