Affiliated Groups - Introduction

Affiliated Groups - Pelizzola

RNA modifications in physiology and disease biology

PI: M.Pelizzola – affiliated UniBicocca

RNA molecules undergo a wide range of chemical modifications that regulate their function across all stages of the RNA life cycle, including transcription, processing, stability and translation.

This research focuses on understanding the distribution, molecular functions and biological roles of RNA modifications by integrating experimental and computational approaches.

Relevance on human disease
RNA modification pathways remain largely unexplored in many diseases, including cancer and developmental disorders. Their characterization may open new avenues for diagnostic and therapeutic strategies.
 

RNA modifications in physiology and disease biology

PI: M.Pelizzola – affiliated UniBicocca

RNA molecules undergo a wide range of chemical modifications that regulate their function across all stages of the RNA life cycle, including transcription, processing, stability and translation.

This research focuses on understanding the distribution, molecular functions and biological roles of RNA modifications by integrating experimental and computational approaches.

Relevance on human disease
RNA modification pathways remain largely unexplored in many diseases, including cancer and developmental disorders. Their characterization may open new avenues for diagnostic and therapeutic strategies.
 

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Affiliated Groups - Campaner

Transcriptional and post-transcriptional control mechanisms in cancer

PI: S.Campaner – affiliated UniPadova

Cancer evolution is driven by genetic, epigenetic and transcriptional alterations that enable tumor growth, adaptation and resistance to therapy.

This research investigates transcriptional and post-transcriptional regulatory mechanisms in cancer using advanced genomic technologies, including bulk, single-cell and long-read sequencing, combined with functional approaches such as CRISPR-based screening.

Relevance on human disease
Understanding how cancer cells regulate gene expression provides a foundation for identifying new biomarkers and therapeutic targets.
 

Transcriptional and post-transcriptional control mechanisms in cancer

PI: S.Campaner – affiliated UniPadova

Cancer evolution is driven by genetic, epigenetic and transcriptional alterations that enable tumor growth, adaptation and resistance to therapy.

This research investigates transcriptional and post-transcriptional regulatory mechanisms in cancer using advanced genomic technologies, including bulk, single-cell and long-read sequencing, combined with functional approaches such as CRISPR-based screening.

Relevance on human disease
Understanding how cancer cells regulate gene expression provides a foundation for identifying new biomarkers and therapeutic targets.