Beatrice Borhy

RESEARCH PROJECT: Characterisation of the molecular mechanisms leading to RNA Binding Protein's altered levels and activity in oxidative stress conditions in sporadic ALS.

THEMATIC AREA: Molecular Biology of Stem Cells (BIO-11).

EDUCATION:

2023-Ongoing - PhD in Life Sciences (XXXIX cycle). Sapienza University of Rome. Curriculum: Cellular and Molecular Biology and Genetics of eukaryotic cells; Developmental Biology; Cellular Physiology. Supervisor: Professor Alessandro Rosa.

2021-2023 - Master's Degree in Genetics and Molecular Biology (110/110 cum laude). Sapienza University of Rome. 
Thesis: Generation of iPSC-derived systems for modeling chronic stress in sporadic Amyotrophic Lateral Sclerosis. 
Supervisor: Professor Alessandro Rosa.

2017-2021- Bachelor's Degree in Biological Sciences (110/110 cum laude). Tuscia University.
Thesis: Drosophila melanogaster as a model system for the study of human neurodegenerative diseases.
Supervisor: Professor Giorgio Prantera.

PhD PROJECT:
My research project will focus on the study of RNA-binding proteins (RBPs) involved in Amyotrophic Lateral Sclerosis (ALS). In vitro models will be used based on induced pluripotent stem cells (iPSC), with or without mutations in disease-genes, which will be differentiated to obtain cell types involved in the disease, primarily Motor Neurons and Skeletal Muscle Cells, also in co-culture. These cell systems reproduce, under conditions of oxidative stress, phenotypes relevant to modelling sporadic ALS.